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China Oncology ›› 2022, Vol. 32 ›› Issue (4): 357-362.doi: 10.19401/j.cnki.1007-3639.2022.04.009
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ZHOU Changshuai1(
)(
), YANG Yuechao1, CUI Huanhuan1, CHEN Lei1, CHEN Xin1, HAO Bin1, TONG Tong2, CAO Yiqun1()()
Received:2022-01-19
Revised:2022-02-20
Online:2022-04-30
Published:2022-05-07
Contact:
CAO Yiqun
E-mail:zhoucs1682@163.com;gem23@163.com
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ZHOU Changshuai, YANG Yuechao, CUI Huanhuan, CHEN Lei, CHEN Xin, HAO Bin, TONG Tong, CAO Yiqun. Prognostic factor analysis of surgical treatment for cerebellar metastases in 36 patients[J]. China Oncology, 2022, 32(4): 357-362.
Tab. 1
Clinicopathological features of 36 patients with cerebellar metastases"
| Factors | n=36 |
|---|---|
| Age/year | 58.75±8.99 |
| Female | 16 (44.44%) |
| Extracranial metastasis | 23 (63.89%) |
| Lesions | |
| 1 | 18 (50.00%) |
| 2 | 10 (27.78%) |
| ≥3 | 8 (22.22%) |
| Diameter D/cm | |
| ≥3 | 24 (66.67%) |
| <3 | 12 (33.33%) |
| Location | |
| Cerebellar metastases | 19 (52.78%) |
| Combined supratentorial metastases | 17 (47.22%) |
| Peritumoral edema | |
| Light | 16 (44.44%) |
| Moderate | 11 (30.56%) |
| Severe | 9 (25.00%) |
| Primary tumor | |
| Lung cancer | 19 (52.78%) |
| Breast cancer | 7 (19.44%) |
| Colorectal cancer | 4 (11.11%) |
| Gynecological tumor | 2 (5.56%) |
| Melanoma | 2 (5.56%) |
| Renal carcinoma | 1 (2.78%) |
| Pancreatic cancer | 1 (2.78%) |
| Ki-67 proliferation index | |
| <50% | 15 (41.67%) |
| ≥50% | 21 (58.33%) |
| Postoperative targeted therapy | 18 (50.00%) |
| Postoperative radiotherapy | 20 (55.56%) |
Fig. 1
Left cerebellar metastasis A: Preoperative; B: Postoperative."
Tab. 2
Univariate and multivariate Cox regression analysis of 36 cases of cerebellar metastases"
| Characteristics | Case (n=36) | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|---|
| Hazard ratio (95% CI) | P value | Hazard ratio (95% CI) | P value | ||
| Age (≥65 years) | 9 | 1.838 (0.727-4.646) | 0.198 | ||
| Gender (male) | 20 | 1.854 (0.747-4.606) | 0.183 | ||
| Extracranial metastasis | 23 | 1.696 (0.656-4.384) | 0.276 | ||
| KPS score≥70 | 24 | 0.767 (0.316-1.865) | 0.559 | ||
| Diameter ≥3 cm | 24 | 0.739 (0.287-1.904) | 0.531 | ||
| Multiple lesions (≥3) | 8 | 3.393 (1.371-8.400) | 0.008 | 2.079 (0.516-8.375) | 0.303 |
| Combined supratentorial metastases | 17 | 2.334 (0.949-5.739) | 0.065 | 1.517 (0.432-5.332) | 0.515 |
| Peritumoral edema (severe) | 9 | 0.524 (0.166-1.659) | 0.272 | ||
| Postoperative radiotherapy | 20 | 0.262 (0.106-0.648) | 0.004 | 0.040 (0.008-0.196) | <0.001 |
| Postoperative targeted therapy | 18 | 0.321 (0.122-0.846) | 0.022 | 0.178 (0.052-0.602) | 0.006 |
| Ki-67 proliferation index ≥50% | 21 | 3.543 (1.255-10.002) | 0.017 | 3.772 (1.067-13.336) | 0.039 |
Fig. 2
Kaplan-Meier survival analysis of prognostic factors after cerebellar metastases resection A: Ki-67 index; B: Postoperative targeted therapy; C: Postoperative radiotherapy; D: Number of lesions."
Fig. 3
Kaplan-Meier survival analysis of peritumoral edema of cerebellar metastases"
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