Abstract: Giant cell tumors of bone (GCTB) in the spine are rarely seen, and the diagnosis relies on clinical presentations, imaging and pathology. The treatment of spinal giant cell tumor is difficult because there is no evidencebased management guidelines and consensus. Surgery is still the first choice for management of the spinal giant cell tumor. Preoperative arterial embolization and complete surgical removal with postoperative denosumab are the recommended treatment methods. En bloc resection is an ideal treatment for spinal giant cell tumors, but surgeons must carefully evaluate patients individually. Denosumab is indicated for patients with unresectable/recurrent/metastatic GCTB. It can effectively reduce the stage of giant GCTB and create conditions for en bloc resection.

Key words: Spine, Giant cell tumor of bone, Surgery, Adjuvant therapy