Abstract: The prognose of cancer patient with peritoneal metastatic carcinoma remains poor. A combined treatment approach of cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC), a standard remedy for peritoneal metastatic carcinoma, is only applicable to a handful of patients. Relevant research so far has shown that the biological features and local immune microenvironment of peritoneal metastatic carcinoma undergo significant changes. Besides, the lipid of the peritoneum is a special and important component of the microenvironment of peritoneal metastatic tumor. Further study of the local microenvironment of peritoneal metastatic carcinoma will help to reveal the mechanisms of peritoneal metastasis and provide beneficial exploration for the development of new treatments.

Key words: Neoplasm, Peritoneal metastasis, Ascites, Immune microenvironment, Immune cells, Adipose tissue