China Oncology ›› 2023, Vol. 33 ›› Issue (9): 866-873.doi: 10.19401/j.cnki.1007-3639.2023.09.007
• Review • Previous Articles Next Articles
LI Xinran1,2(), LIANG Yiyi1, TU Hong1()
Received:
2022-12-02
Revised:
2023-03-01
Online:
2023-09-30
Published:
2023-10-01
Contact:
TU Hong.
CLC Number:
LI Xinran, LIANG Yiyi, TU Hong. Research progress of the intratumoral microbiome[J]. China Oncology, 2023, 33(9): 866-873.
Tab.1
The main microbial species in human cancers and their roles and possible mechanisms in cancer occurrence and progression"
Cancer type | Microbial species | Function | Mechanism | Reference |
---|---|---|---|---|
Melanoma | Propionibacterium; Staphylococcus aureus; Corynebacterium | Promote cancer growth | Melanoma cells present HLA-conjugated intracellular bacterial peptides to activate T cell immune responses | [ |
Ovarian cancer | Proteobacteria; Firmicutes | Promote cancer growth and metastasis | Up-regulate the expression of TLR5 in tumor cells to promote the mobilization of MDSC; LPS up-regulates the expression of PI3K, EMT and metastasis-related genes in tumor cells | [ |
Nasopharyngeal carcinoma | Corynebacterium; Staphylococcus aureus | Promote cancer recurrence | The increase of bacteria in tumor is negatively correlated with tumor infiltration of CD8+ T cells | [ |
Brain glioma | Pseudomonas; Erythrobacillus; Actinomycetes | Promote cancer growth | Secretion of fatty acids, LPS and other metabolites through the brain-intestinal axis affects the central nervous system immunity | [ |
Bone tumour | Pseudomonas; Actinomycetes | Promote cancer growth | Degrade the hydroxyproline that makes up bone collagen | [ |
Colorectal cancer | Firmicutes; Bacteroidetes; Fusobacterium nucleatum | Promote cancer invasion and metastasis | Down-regulate the expression of m6A methyltransferase METTL3 in tumor tissue and enhance tumor invasiveness; CD8+ T cell infiltration in liver metastases is decreased and MDSC infiltration is increased to inhibit anti-tumor immune response | [ |
Prostate cancer | Pseudomonas; Escherichia coli | Inhibit cancer metastasis and improve the efficacy of immunotherapy | Negatively associated with tumor metastasis; Enhance the immunogenicity of tumor cells; Increase tumor infiltration of immune effector cells | [ |
Gastric carcinoma | Peptostreptococcus Streptococcus; Fusobacterium nucleatum | Promote cancer growth or improve the efficacy of immunotherapy | Increase the content of N-nitrite compounds in the stomach and promote the colonization of harmful bacteria; Increase the expression of PD-L1 in gastric epithelial cells and induce T cell apoptosis; Up-regulate the purine metabolic pathway of the tumor flora, enhancing the immune response | [ |
Cutaneous T-cell lymphoma | Corynebacterium; Staphylococcus aureus | Promote cancer growth | Staphylococcal α-toxin induces normal cell death, while tumor cells are resistant; Inhibition of T cell killing promotes tumor immune escape | [ |
Oral squamous cell carcinoma | Fusobacterium nucleatum; Monad; Prevotella copri | Promote cancer growth and invasion | LPS promotes the release of IL-1 and VEGF in tumor and mononuclear cells and enhances tumor invasiveness; Bacterial metabolites such as acetaldehyde cause DNA damage and over proliferation of epithelial cells | [ |
Squamous cell carcinoma of head and neck | Fusobacterium; Staphylococcus aureus | Promote chronic inflammation; Promote cancer invasion | The amount of bacteria is positively correlated with the tumor infiltration of macrophages and promotes the inflammatory tumor microenvironment; Up-regulate EMT-related signaling molecules in tumor cells | [ |
Esophagus cancer | Fusobacterium; Proteobacteria | Promote cancer occurrence | LPS promotes cancer by promoting the release of inflammation-related mediators | [ |
Gallbladder cancer | Campylobacter; Phyllobacterium | Associated with survival and lymph node metastasis | Not involved | [ |
Bladder cancer | Staphylococcus aureus; Corynebacterium | Promote cancer progression and recurrence | Up-regulate the expression of PD-L1 in cancer tissues and promote immune escape | [ |
Cervical cancer | Lactobacillus; Fusobacterium | Promote cancer growth | Promote Th cells to secrete IL-1β, IL-6 and IL-8 to promote inflammation and inhibit anti-tumor immune response; Induce the accumulation of sphinolipids and glycerols in the outer membrane of cervical epithelial cells, leading to cell damage and the formation of pro-inflammatory microenvironment | [ |
Endometrial cancer | Porphyromonas; Bacteroides; Bacillus faecalis | Induce and promote cancer growth | Activate endometrial cells to produce pro-inflammatory cytokines; Release toxins that damage host DNA and induce autophagy and carcinogenesis | [ |
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