Application consensus of peripheral blood HER2 gene amplification detection (digital PCR) in anti-HER2 therapy

doi:10.19401/j.cnki.1007-3639.2022.01.012

Abstract

CLC Number:

R737.9

LU Renquan, LIU Guangyu, YANG Wentao, GUO Lin, GUAN Ming, SHAO Zhimin, XU Dazhi, NI Ming, TANG Feng, WANG Chaofu, LOU Jiatao, SUN Fenyong, XING Jinliang, PAN Yueyin. Application consensus of peripheral blood HER2 gene amplification detection (digital PCR) in anti-HER2 therapy[J]. China Oncology, 2022, 32(1): 90-96.

Figures/Tables 2

References 25

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Detection result of dPCR	Detection results of gold standard for tissue sample detection (ICH combined with FISH)		Total
Detection result of dPCR	Positive	Negative	Total
Positive	42	20	62
Negative	54	106	160
Total	96	126	222

Item	Newly diagnosed stage Ⅲ patients (n=70)	Newly diagnosed stage Ⅳ patients (n=93)	Patients with recurrence and metastasis (n=59)
Sensitivity	37.93% (11/29)	41.67% (15/36)	51.61% (16/31)
Specificity	92.68% (38/41)	85.96% (49/57)	67.86% (19/28)
Total consistent rate	70.00% (49/70)	68.82% (64/93)	59.32% (35/59)
Kappa	0.331 2	0.296 0	0.192 7

Application consensus of peripheral blood HER2 gene amplification detection (digital PCR) in anti-HER2 therapy

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