Abstract:

Gastric cancer is one of the most common malignant tumors, and over 70% of patients were diagnosed as advanced stage at the first visit in our country. For patients with locally advanced gastric cancer invading adjacent organs, the diagnosis and surgical treatment are quite difficult, and prognosis is poor. To further standardize the clinical research practice of locally advanced gastric cancer invading adjacent organs, this consensus was guided by evidence-based methodology, focusing on the progress of diagnosis and treatment in locally advanced gastric cancer invading adjacent organs, and the clinical studies with high level of evidence but not approved at present, and exploring the new modes of diagnosis, efficacy evaluation and other aspects. On the basis of literature retrieval, quality evaluation and evidence summary were carried out, and specific issues and hot topics such as the methods of diagnosis, peri-operative treatment, surgical treatment and other common concerns in the clinical application were discussed and investigated through multidisciplinary expert meetings, Delphi methods and other forms. The “Chinese expert consensus on clinical practice of locally advanced gastric cancer invading adjacent organs (2024 edition)” was completed by the investigation and summarization of the opinions of 35 experts from more than 10 different regions and 30 hospitals for 4 times, relying on Professional Committee on Gastric Cancer of Shanghai Anticancer Association, Professional Committee on Gastrointestinal Cancer of China Association for Promotion of Health Science and Technology, with a view to providing evidence reference and normative basis for frontline medical personnel in future clinical practice of locally advanced gastric cancer treatment, and laying a foundation for subsequent development of relevant industry guidelines.

Key words: Locally advanced gastric cancer, Invading adjacent organs, Expert consensus, Diagnosis, Treatment