Recent advances of radiation-induced hypoxia on radiation-induced normal tissue injury

doi:10.3969/j.issn.1007-3969.2014.12.013

China Oncology ›› 2014, Vol. 24 ›› Issue (12): 956-960.doi: 10.3969/j.issn.1007-3969.2014.12.013

Recent advances of radiation-induced hypoxia on radiation-induced normal tissue injury

LIU Qi¹, SUN Yong¹, XING Xing^1,2, LIU Yong^1,2

1.Cancer Research Institute, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China;
2.Department of Radiation Oncology, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China

Online:2014-12-30 Published:2015-05-07
Contact: LIU Yong E-mail: drliuyong@hotmail.com

Abstract

Abstract: The dose-limiting factor of radiotherapy is injury found in normal surrounding tumor tissues. It is characterized by inflammation, fibrotic changes, necrosis and other pathological changes. Hypoxic microenvironment is induced in normal tissues received radiation exposure. Previous studies demonstrated radiation-induced hypoxia increased hypoxia inducible factor-lα (HIF-1α), vascular endothelial growth factor (VEGF) and transforming growth factor-β (TGF-β) and other cytokines. They promoted radiation-induced normal tissues injury by HIF-1α signaling pathways, oxidative stress reaction, macrophages and miRNAs. In this study, we reviewed the effect of radiationinduced hypoxic microenvironment on normal tissues injury after radiation exposure.

Key words: Radiation, Normal tissue injury, Hypoxia

LIU Qi, SUN Yong, XING Xing et al. Recent advances of radiation-induced hypoxia on radiation-induced normal tissue injury[J]. China Oncology, 2014, 24(12): 956-960.

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Recent advances of radiation-induced hypoxia on radiation-induced normal tissue injury

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