China Oncology ›› 2023, Vol. 33 ›› Issue (10): 920-926.doi: 10.19401/j.cnki.1007-3639.2023.10.004
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CHENG Weihao(), WANG Weili, BI Zhao, ZHANG Chaopeng, SUN Xiao, ZHAO Jiaxian, QIU Pengfei, CHEN Peng, WANG Yongsheng()
Received:
2023-07-19
Revised:
2023-09-18
Online:
2023-10-30
Published:
2023-10-31
Contact:
WANG Yongsheng.
CLC Number:
CHENG Weihao, WANG Weili, BI Zhao, ZHANG Chaopeng, SUN Xiao, ZHAO Jiaxian, QIU Pengfei, CHEN Peng, WANG Yongsheng. Timing of surgery and risk of postoperative thrombotic complications after recovery from Covid-19 in breast cancer patients[J]. China Oncology, 2023, 33(10): 920-926.
Tab. 1
The clinical characteristics of breast cancer patients [n (%)]"
Characteristic | Pre-COVID-19 surgery before September 30, 2019 | Peri-COVID-19 surgery 0 to 2 weeks after COVID-19 | Early post-COVID-19 surgery 3 to 4 weeks after COVID-19 | Early post-COVID-19 surgery 5 to 6 weeks after COVID-19 | Early post-COVID-19 surgery 7 to 8 weeks after COVID-19 | Late post-COVID-19 surgery at least 8 weeks after COVID-19 |
---|---|---|---|---|---|---|
Clinical N stage | ||||||
cN0 | 226 (68.7) | 11 (64.7) | 13 (44.8) | 24 (77.4) | 30 (60.0) | 127 (66.8) |
cN1 | 72 (21.9) | 5 (29.4) | 10 (34.6) | 2 (6.5) | 15 (30.0) | 41 (21.6) |
cN2 | 13 (3.9) | 1 (5.9) | 3 (10.3) | 3 (9.6) | 4 (8.0) | 15 (7.8) |
cN3 | 18 (5.5) | 0 (0.0) | 3 (10.3) | 2 (6.5) | 1 (2.0) | 7 (3.4) |
Clinical T stage | ||||||
cT1 | 206 (62.6) | 7 (41.2) | 10 (34.6) | 19 (61.3) | 23 (46.0) | 105 (55.3) |
cT2 | 116 (35.3) | 9 (52.9) | 16 (55.1) | 8 (25.8) | 22 (44.0) | 77 (40.5) |
cT3 | 3 (0.9) | 0 (0.0) | 3 (10.3) | 3 (9.7) | 1 (2.0) | 5 (2.6) |
cT4 | 4 (1.2) | 1 (5.9) | 0 (0.0) | 1 (3.2) | 4 (8.0) | 3 (1.6) |
Breast surgery | ||||||
Mastectomy±PI | 259 (78.7) | 9 (52.9) | 22 (75.8) | 19 (61.3) | 37 (74.0) | 119 (62.6) |
BCS | 70 (21.3) | 8 (47.1) | 7 (24.2) | 12 (38.7) | 13 (36.0) | 71 (37.4) |
Concomitant syndromes | ||||||
Hypertension | 33 (10.0) | 2 (11.8) | 5 (17.2) | 3 (9.7) | 6 (12.0) | 19 (10.0) |
Diabetes | 7 (2.1) | 1 (5.9) | 0 (0.0) | 1 (3.2) | 2 (4.0) | 10 (5.2) |
Liver disease | 20 (6.1) | 1 (5.9) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 2 (1.1) |
Stroke | 2 (0.6) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 2 (1.1) |
CAD | 1 (0.3) | 0 (0.0) | 1 (3.4) | 0 (0.0) | 0 (0.0) | 3 (1.5) |
COVID-19 severity | ||||||
Asymptomatic/mild | NA | 16 (94.1) | 28 (96.5) | 31 (100.0) | 49 (98.0) | 189 (99.5) |
Severe | NA | 1 (5.9) | 1 (3.4) | 0 (0.0) | 1 (2.0) | 1 (0.5) |
Tab. 2
Analysis of postoperative thrombus complications in breast cancer patients"
Groups | DVT | |
---|---|---|
No. | Percentage/% | |
Pre-COVID-19 surgery before September 30, 2019 (n = 329) | 4 | 1.21 |
Peri-COVID-19 surgery 0 to 2 weeks after COVID-19 (n = 17) | 2 | 11.76 |
Early post-COVID-19 surgery 3 to 4 weeks after COVID-19 (n = 29) | 1 | 3.45 |
Early post-COVID-19 surgery 5 to 6 weeks after COVID-19 (n = 31) | 1 | 3.23 |
Early post-COVID-19 surgery 7 to 8 weeks after COVID-19 (n = 50) | 3 | 6.00 |
Late post-COVID-19 surgery at least 8 weeks after COVID-19 (n = 190) | 3 | 1.58 |
Tab. 3
The univariate analysis of postoperative DVT"
Characteristics | DVT | P value | |
---|---|---|---|
Yes | No | ||
Age/year | 0.541 | ||
<50 | 6 | 323 | |
≥50 | 8 | 309 | |
Clinical N stage | 0.094 | ||
cN0 | 7 | 424 | |
cN1 | 3 | 142 | |
cN2 | 3 | 36 | |
cN3 | 1 | 30 | |
Clinical T stage | 0.627 | ||
cT1 | 8 | 362 | |
cT2 | 5 | 243 | |
cT3 | 1 | 14 | |
cT4 | 0 | 13 | |
Breast surgery | 0.558 | ||
Mastectomy±PI | 10 | 493 | |
BCS | 4 | 139 | |
Groups | 0.024 | ||
Pre-covid | 4 | 325 | |
0-2 weeks | 2 | 15 | |
3-8 weeks | 5 | 105 | |
>8 weeks | 3 | 187 |
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