关键词: 钇-90微球, 选择性内放射治疗, 肝细胞癌

Abstract: Hepatocellular carcinoma (HCC) is the second most common cause of cancer-related deaths in China. About 85% of HCC patients are at intermediate or advanced stage upon diagnosis, of which the common treatment strategy is the combination of systemic therapy (including chemotherapy, targeted therapy and immunotherapy) and local minimally invasive therapy (such as interventional therapy and radiotherapy). As one of the local minimally invasive treatment modalities, selective internal radiation therapy (SIRT) with yttrium-90 ( ⁹⁰ Y) microspheres has been used for nearly 20 years abroad with confirmed efficacy and safety. Benefit in local control of HCC by using SIRT with  ⁹⁰ Y microspheres alone or being combined with surgery, immunotherapy and targeted drugs has been demonstrated. Meanwhile, the “radiation resection” effect of SIRT with  ⁹⁰ Y microsphere on liver segments sheds light on its promising clinical use as radical treatment for HCC. Herein, the application and recent progress of SIRT with  ⁹⁰ Y microspheres in HCC were reviewed in terms of its therapeutic purpose as palliative, transformation or radiation segmentectomy.

Key words:  Yttrium-90 microspheres, Selective internal radiation therapy, Hepatocellular carcinoma