中国癌症杂志 ›› 2021, Vol. 31 ›› Issue (5): 428-434.doi: 10.19401/j.cnki.1007-3639.2021.05.009

• 综述 • 上一篇    下一篇

90 Y微球选择性内放射治疗在肝细胞癌中的应用及研究进展

牛 娜 综述 ,林岩松  审校
  

  1. 中国医学科学院北京协和医学院北京协和医院核医学科,北京 100730
  • 出版日期:2021-05-30 发布日期:2021-05-31
  • 通信作者: 林岩松 E-mail: linys@pumch.cn

Application and research progress of selective internal radiation therapy with  90 Y microspheres in hepatocellular carcinoma

NIU Na, LIN Yansong   

  1. Application and research progress of selective internal radiation therapy with  90 Y microspheres in hepatocellular carcinoma
  • Online:2021-05-30 Published:2021-05-31
  • Contact: LIN Yansong E-mail: linys@pumch.cn

摘要: 肝细胞癌(hepatocellular carcinoma,HCC)是中国癌症相关死亡第二大常见原因。中国约85%的HCC患者在确诊时已是中晚期,系统治疗(包括化疗、靶向治疗、免疫治疗)联合局部微创治疗(如介入治疗、放射治疗等)是目前主要的治疗方式。钇-90(yttrium-90, 90 Y)微球选择性内放射治疗(selective internal radiation therapy,SIRT)作为主要局部微创治疗手段在国外已有近20年的临床使用经验,临床研究证明了其治疗肝脏肿瘤的疗效和安全性。相关研究证实了 90 Y微球SIRT单用在HCC中的局部控制作用,以及其与手术、免疫药物、靶向药物联用的有效性及安全性,同时, 90 Y微球SIRT对于肝段产生的“放射性切除”效应初步显示出其在HCC根治性治疗方面的应用前景。从HCC姑息治疗、转化治疗、放射性肝段切除等方面综述SIRT在HCC中的应用及研究进展。

关键词: 钇-90微球, 选择性内放射治疗, 肝细胞癌

Abstract: Hepatocellular carcinoma (HCC) is the second most common cause of cancer-related deaths in China. About 85% of HCC patients are at intermediate or advanced stage upon diagnosis, of which the common treatment strategy is the combination of systemic therapy (including chemotherapy, targeted therapy and immunotherapy) and local minimally invasive therapy (such as interventional therapy and radiotherapy). As one of the local minimally invasive treatment modalities, selective internal radiation therapy (SIRT) with yttrium-90 ( 90 Y) microspheres has been used for nearly 20 years abroad with confirmed efficacy and safety. Benefit in local control of HCC by using SIRT with  90 Y microspheres alone or being combined with surgery, immunotherapy and targeted drugs has been demonstrated. Meanwhile, the “radiation resection” effect of SIRT with  90 Y microsphere on liver segments sheds light on its promising clinical use as radical treatment for HCC. Herein, the application and recent progress of SIRT with  90 Y microspheres in HCC were reviewed in terms of its therapeutic purpose as palliative, transformation or radiation segmentectomy.

Key words:  Yttrium-90 microspheres, Selective internal radiation therapy, Hepatocellular carcinoma