关键词: 神经内分泌肿瘤, 流行病学, 病理特点

Abstract:

Background and purpose: Neuroendocrine neoplasm is one kind of infrequent neoplasms from neuroendocrine cell and peptidergic neurons. This study aimed to investigate the epidemiology and clinicopathological characteristics of neuroendocrine neoplasms (NEN) in Dalian. Methods: We retrospectively analyzed all neuroendocrine neoplasms patients in First Affiliated Hospital of Dalian Medical University from 2000 to 2013. The epidemiology characteristics, pathogenic sites and pathological types were reviewed, and the differences between gender and age were also analyzed. The statistics analysis such as independent-samples t test and one-way ANOVA and chi-square test were performed. Results: There were 279 NEN cases, including 166 male and 113 female patients (male: female=1.14: 1), detection rate was 0.258%. The mean age of all cases was 59.4±17.1 (20-83), for male 58.9±19.4 (20-81) and female 61.7±15.0 (29-83). There was no statistical significance of detection rate and mean age between male and female patients. Digestive system was the most common occurred site of NEN (71.68%), then was the respiratory system (20.79%). There was no statistical significance of pathogenic sites between male and female. In all case, 132 with neuroendocrine tumor (47.31%), 140 with neuroendocrine cancer (50.18%), 7 with mixed adenoneuroendocrine carcinoma (2.51%). There was no statistical significance of pathological types between male and female (P>0.05).Conclusion: Recently, the detection rate of neuroendocrine neoplasms was raised in Dalian, but there was no significance differences in detection rate，pathogenic sites and pathological types between male and female.

Key words: Neuroendocrine neoplasms, Epidemiology, Clinicopathological characteristics