中国癌症杂志 ›› 2020, Vol. 30 ›› Issue (10): 759-769.doi: 10.19401/j.cnki.1007-3639.2020.10.006

• 专家述评与论著 • 上一篇    下一篇

肺癌发病分子机理研究新进展:从基础到临床

金宇娟,胡 良,季红斌   

  1. 中国科学院分子细胞科学卓越创新中心,上海 200031
  • 出版日期:2020-10-30 发布日期:2020-11-12
  • 通信作者: 季红斌 E-mail: hbji@sibcb.ac.cn

Advances in molecular mechanism of lung cancer: from rational to practice

JIN Yujuan, HU Liang, JI Hongbin#br#   

  1. Chinese Academy of Sciences Center for Excellence in Molecular Cell Science, Shanghai 200031, China
  • Published:2020-10-30 Online:2020-11-12
  • Contact: JI Hongbin E-mail: hbji@sibcb.ac.cn

摘要: 肺癌在全球范围内具有非常高的发病率和致死率,严重着威胁人类健康。影响肺癌发生、发展及转移的因素十分复杂,可大致分为肿瘤细胞自身因素和肿瘤微环境因素:一方面,肿瘤细胞内基因组、蛋白质组水平的改变,在一定程度上决定了肺癌的特征;另一方面,肿瘤微环境包括免疫微环境和非免疫微环境,显著地影响肺癌的发生、发展。因此,深入研究肺癌自身及其微环境将有助于加深人们对肺癌发病分子机理的认识,并为改进肺癌的临床诊疗手段奠定重要的理论基础,帮助提高肺癌患者的生活质量及生存时间。对肺癌基础研究的现状进行综述,重点回顾肺癌基因组、蛋白质组、表型可塑性及肺癌微环境领域的相关研究进展,并讨论肺癌临床治疗的新策略。

关键词: 肺癌, 基因组学, 蛋白质组学, 肿瘤可塑性, 肿瘤微环境

Abstract: Lung cancer is one of the most malignant carcinomas worldwide, with extremely high incidence and mortality. The factors that affect lung cancer initiation, progression and metastasis are complicated, which could be roughly divided into two parts, from either cancer cells themselves or tumor-associated microenvironment. On the one hand, genomic and proteomic alterations in cancer cells determinate their characteristics. On the other hand, tumor microenvironment, including both immune and non-immune microenvironments, significantly affect tumorigenesis and malignant progression. Studies in lung cancer and its microenvironment help improve the understanding of molecular mechanisms, and lay an important theoretical foundation to the clinical diagnosis and therapy. In this review, we summarized recent progress of lung cancer genomics, proteomics, phenotypic plasticity and microenvironment, and discussed potential therapeutic strategies for clinical treatment.

Key words: Lung cancer, Genomics, Proteomics, Tumor plasticity, Tumor microenvironment