China Oncology ›› 2019, Vol. 29 ›› Issue (3): 161-165.doi: 10.19401/j.cnki.1007-3639.2019.03.001

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Issues on immunohistochemistry for molecular classification of breast cancer

SUN Xiangjie, YANG Wentao   

  1. Department of Pathology, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China
  • Online:2019-03-30 Published:2019-04-26
  • Contact: YANG Wentao E-mail: yangwt2000@163.com

Abstract: Currently, there are 4 intrinsic subtypes of breast cancer identified by gene expression profiling: luminal A, luminal B, human epidermal growth factor receptor 2 (HER2)-enriched and basal-like subtypes. As the application of gene expression profiling in daily practice is not practical, using immunohistochemistry as a surrogate for intrinsic subtypes are used worldwide. This review aimed to standardize and promote the immunohistochemistry for molecular classification of breast cancer.

Key words: Breast cancer, Molecular classification, Immunohistochemistry