China Oncology ›› 2020, Vol. 30 ›› Issue (9): 701-706.doi: 10.19401/j.cnki.1007-3639.2020.09.010

• Review • Previous Articles     Next Articles

Advances in research of exosomes as targeted therapeutic vectors

PAN Xinghao, LIU Mingbin, ZHANG Xiaoyan, XU Jianqing   

  1. Shanghai Public Health Clinical Center Affiliated to Fudan University, Shanghai 201508, China
  • Online:2020-09-30 Published:2020-10-13
  • Contact: XU Jianqing E-mail: xujiangqing@shphc.org.cn

Abstract: Exosomes are nanoscale vesicles derived from the inner membrane of cells, containing life information such as nucleic acids, proteins and lipids. They play an important role in life activities as a mechanism of intercellular communication. Compared to liposome carriers, exosomes are more stable, biocompatible and less immunogenic, and can penetrate biological barriers such as the blood-brain barrier and the placental barrier. This article focused on the basis of exosome vector targeting, the method of carrier loading and the current application progress and prospects.

Key words: Exosomes, Targeting, Therapeutic vector