Abstract: Clonal hematopoiesis (CH) is mutation derived from hematopoietic stem cell (HSC). It is the result of the joint action of age and external environment (smoking, radiotherapy and chemotherapy, etc.). With the development of tumor genomics, genetic testing has become an important part in the whole course medical management of patients with tumor. The value of CH in solid tumors has attracted more and more attention. Focusing on the detection of CH, this review described in detail the detection methods of CH in tissue samples and circulating tumor DNA (ctDNA) samples. Furthermore, we explored the influence and challenge of CH on the detection of somatic mutation in tumors.

Key words: Clonal hematopoiesis, Tumor, Genetic testing, Circulating tumor DNA, Somatic mutation