China Oncology ›› 2022, Vol. 32 ›› Issue (6): 499-511.doi: 10.19401/j.cnki.1007-3639.2022.06.004
• Specialists' Commentary • Previous Articles Next Articles
HU Xichun1,#()(), HU Zhihuang2,#()(), WANG Biyun3, WANG Jialei2, TAO Rong4, ZHANG Jian5, GUO Weijian6, CHEN Jie7, LUO Zhiguo1, LI Ting3, HUANG Mingzhu6, QIU Lixin6, SANG Youzhou7
Received:
2022-05-08
Revised:
2022-05-20
Online:
2022-06-30
Published:
2022-07-21
Contact:
HU Xichun
E-mail:xchu2009@hotmail.com;ZhihuangHu@hotmail.com
CLC Number:
HU Xichun, HU Zhihuang, WANG Biyun, WANG Jialei, TAO Rong, ZHANG Jian, GUO Weijian, CHEN Jie, LUO Zhiguo, LI Ting, HUANG Mingzhu, QIU Lixin, SANG Youzhou. COVID-19 and systemic anti-cancer therapy[J]. China Oncology, 2022, 32(6): 499-511.
[1] | 国家卫生健康委员会办公厅,国家中医药管理局办公室.新型冠状病毒肺炎诊疗方案(试行第九版)[EB/OL][2022-04-20]http://www.nhc.gov.cn/yzygj/s7653p/202203/b74ade1ba4494583805a3d2e40093d88.shtml, 2022. |
General Office of the National Health Commission, Office of the State Administration of Traditional Chinese Medicine.Diagnosis and treatment plan for novel coronavirus pneumonia (trial version 9)[EB/OL][2022-04-20].>http://www.nhc.gov.cn/yzygj/s7653p/202203/b74ade1ba4494583805a3d2e40093d88.shtml, 2022. | |
[2] |
ZENG C,, EVANS J P,, REISINGER S, et al.Impaired neutralizing antibody response to COVID-19 mRNA vaccines in cancer patients[J]. Cell Biosci, 2021, 11(1): 197.
doi: 10.1186/s13578-021-00713-2 |
[3] | PASSAMONTI F,, CATTANEO C,, ARCAINI L, et al.Clinical characteristics and risk factors associated with COVID-19 severity in patients with haematological malignancies in Italy: a retrospective, multicentre, cohort study[J]. Lancet Haematol, 2020, 7(10): e737-e745. |
[4] |
VAN KAMPEN J J A, VAN DE VIJVER D A M C, FRAAIJ P L A, et al.Duration and key determinants of infectious virus shedding in hospitalized patients with coronavirus disease-2019 (COVID-19)[J]. Nat Commun, 2021, 12(1): 267.
doi: 10.1038/s41467-020-20568-4 |
[5] |
GOUBET A G,, DUBUISSON A,, GERAUD A, et al.Prolonged SARS-CoV-2 RNA virus shedding and lymphopenia are hallmarks of COVID-19 in cancer patients with poor prognosis[J]. Cell Death Differ, 2021, 28(12): 3297-3315.
doi: 10.1038/s41418-021-00817-9 |
[6] |
ROGADO J,, GULLÓN P,, OBISPO B, et al.Prolonged SARS-CoV-2 viral shedding in patients with solid tumours and associated factors[J]. Eur J Cancer, 2021, 148: 58-60.
doi: 10.1016/j.ejca.2021.02.011 |
[7] | BABADY N E,, COHEN B,, MCCLURE T, et al.Variable duration of viral shedding in cancer patients with coronavirus disease 2019 (COVID-19)[J]. Infect Control Hosp Epidemiol, 2021: 1-3. |
[8] |
AYDILLO T,, GONZALEZ-REICHE A S,, ASLAM S, et al.Shedding of viable SARS-CoV-2 after immunosuppressive therapy for cancer[J]. N Engl J Med, 2020, 383(26): 2586-2588.
doi: 10.1056/NEJMc2031670 |
[9] | GOYAL A,, CARDOZO-OJEDA E F,, SCHIFFER J T.Potency and timing of antiviral therapy as determinants of duration of SARS-CoV-2 shedding and intensity of inflammatory response[J]. Sci Adv, 2020, 6(47): eabc7112. |
[10] |
LIU B,, HAN J Y,, CHENG X H, et al.Reduced numbers of T cells and B cells correlates with persistent SARS-CoV-2 presence in non-severe COVID-19 patients[J]. Sci Rep, 2020, 10(1): 17718.
doi: 10.1038/s41598-020-73955-8 |
[11] |
HAMMOND J,, LEISTER-TEBBE H,, GARDNER A, et al.Oral nirmatrelvir for high-risk, nonhospitalized adults with covid-19[J]. N Engl J Med, 2022, 386(15): 1397-1408.
doi: 10.1056/NEJMoa2118542 |
[12] | NCCN.Management of covid-19 infection in patients with cancer[EB/OL]. https://www.nccn.org/docs/default-source/covid-19/2021-covid-infectious-disease-management.pdf?sfvrsn=63f70c30_7, 2021. |
[13] |
LIU Y,, YAN L M,, WAN L G, et al.Viral dynamics in mild and severe cases of COVID-19[J]. Lancet Infect Dis, 2020, 20(6): 656-657.
doi: 10.1016/S1473-3099(20)30232-2 |
[14] | JACOB A S,, KAUL H,, FUCHS M, et al.Impact of the first COVID-19 lockdown in Germany on the rate of acute infections during intensive chemotherapy for Hodgkin lymphoma[J]. Infection, 2022: 1-8. |
[15] |
LIANG W H,, GUAN W J,, CHEN R C, et al.Cancer patients in SARS-CoV-2 infection: a nationwide analysis in China[J]. Lancet Oncol, 2020, 21(3): 335-337.
doi: 10.1016/S1470-2045(20)30096-6 |
[16] |
AYHAN M,, LAÇIN Ş,, ÖZYÜKSELER D T, et al.Does systemic anti-tumor therapy increase COVID-19 risk in patients with cancer?[J]. J Oncol Pharm Pract, 2021, 27(6): 1461-1467.
doi: 10.1177/10781552211015762 |
[17] |
JEE J,, FOOTE M B,, LUMISH M, et al.Chemotherapy and COVID-19 outcomes in patients with cancer[J]. J Clin Oncol, 2020, 38(30): 3538-3546.
doi: 10.1200/JCO.20.01307 |
[18] |
LEE A J X,, PURSHOUSE K.COVID-19 and cancer registries: learning from the first peak of the SARS-CoV-2 pandemic[J]. Br J Cancer, 2021, 124(11): 1777-1784.
doi: 10.1038/s41416-021-01324-x |
[19] |
COELHO D B,, SANTOS V,, ARAÚJO D, et al.Management of coronavirus disease 2019 patients with lung cancer: experience from a thoracic oncology center[J]. Front Mol Biosci, 2021, 8: 639676.
doi: 10.3389/fmolb.2021.639676 |
[20] | SUTANDYO N,, JAYUSMAN A M,, WIDJAJA L, et al.Neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio as mortality predictor of advanced stage non-small cell lung cancer (NSCLC) with COVID-19 in Indonesia[J]. Eur Rev Med Pharmacol Sci, 2021, 25(10): 3868-3878. |
[21] |
LUO J,, RIZVI H,, PREESHAGUL I R, et al.COVID-19 in patients with lung cancer[J]. Ann Oncol, 2020, 31(10): 1386-1396.
doi: 10.1016/j.annonc.2020.06.007 |
[22] | PASSARO A,, BESTVINA C,, VELEZ VELEZ M, et al.Severity of COVID-19 in patients with lung cancer: evidence and challenges[J]. J Immunother Cancer, 2021, 9(3): e002266. |
[23] | VÁRNAI C,, PALLES C,, ARNOLD R, et al.Mortality among adults with cancer undergoing chemotherapy or immunotherapy and infected with COVID-19[J]. JAMA Netw Open, 2022, 5(2): e220130. |
[24] |
GARASSINO M C,, WHISENANT J G,, HUANG L C, et al.COVID-19 in patients with thoracic malignancies (TERAVOLT): first results of an international, registry-based, cohort study[J]. Lancet Oncol, 2020, 21(7): 914-922.
doi: 10.1016/S1470-2045(20)30314-4 |
[25] |
PROVENCIO M,, MAZARICO GALLEGO J M,, CALLES A, et al.Lung cancer patients with COVID-19 in Spain: GRAVID study[J]. Lung Cancer, 2021, 157: 109-115.
doi: 10.1016/j.lungcan.2021.05.014 |
[26] |
HAINEALA B,, ZGURA A,, BADIU D C, et al.Lung cancer, covid-19 infections and chemotherapy[J]. In Vivo, 2021, 35(3): 1877-1880.
doi: 10.21873/invivo.12450 |
[27] |
TRIFANESCU O G,, GALES L,, BACINSCHI X, et al.Impact of the COVID-19 pandemic on treatment and oncologic outcomes for cancer patients in Romania[J]. In Vivo, 2022, 36(2): 934-941.
doi: 10.21873/invivo.12783 |
[28] |
WU Q,, LUO S M,, XIE X H.The impact of anti-tumor approaches on the outcomes of cancer patients with COVID-19: A meta-analysis based on 52 cohorts incorporating 9 231 participants[J]. BMC Cancer, 2022, 22(1): 241.
doi: 10.1186/s12885-022-09320-x |
[29] |
HERMEL D J,, CHAM J,, SPIERLING BAGSIC S R, et al.An observational study of hospitalized COVID-19 patients with cancer in San Diego County[J]. Future Oncol, 2022, 18(6): 719-725.
doi: 10.2217/fon-2021-1116 |
[30] |
YANG K Y,, SHENG Y H,, HUANG C L, et al.Clinical characteristics, outcomes, and risk factors for mortality in patients with cancer and COVID-19 in Hubei, China: a multicentre, retrospective, cohort study[J]. Lancet Oncol, 2020, 21(7): 904-913.
doi: 10.1016/S1470-2045(20)30310-7 |
[31] |
AYHAN M,, LAÇIN Ş,, ÖZYÜKSELER D T, et al.Does systemic anti-tumor therapy increase COVID-19 risk in patients with cancer?[J]. J Oncol Pharm Pract, 2021, 27(6): 1461-1467.
doi: 10.1177/10781552211015762 |
[32] | MANDALA M,, LORIGAN P,, DE LUCA M, et al.SARS-CoV-2 infection and adverse events in patients with cancer receiving immune checkpoint inhibitors: an observational prospective study[J]. J Immunother Cancer, 2021, 9(2): e001694. |
[33] | PASSARO A,, ADDEO A,, VON GARNIER C, et al.ESMO management and treatment adapted recommendations in the COVID-19 era: lung cancer[J]. ESMO Open, 2020, 5(Suppl 3): e000820. |
[34] |
GARASSINO M C,, WHISENANT J G,, HUANG L C, et al.COVID-19 in patients with thoracic malignancies (TERAVOLT): first results of an international, registry-based, cohort study[J]. Lancet Oncol, 2020, 21(7): 914-922.
doi: 10.1016/S1470-2045(20)30314-4 |
[35] |
SO M,, KABATA H,, FUKUNAGA K, et al.Radiological and functional lung sequelae of COVID-19: a systematic review and meta-analysis[J]. BMC Pulm Med, 2021, 21(1): 97.
doi: 10.1186/s12890-021-01463-0 |
[36] | PINATO D J,, ZAMBELLI A,, AGUILAR-COMPANY J, et al.Clinical portrait of the SARS-CoV-2 epidemic in European cancer patients[J]. Cancer Discov, 2020: CD-20-0773. |
[37] |
VUAGNAT P,, FRELAUT M,, RAMTOHUL T, et al.COVID-19 in breast cancer patients: a cohort at the Institut Curie hospitals in the Paris area[J]. Breast Cancer Res, 2020, 22(1): 55.
doi: 10.1186/s13058-020-01293-8 |
[38] |
WEI J L,, WU M J,, LIU J, et al.Characteristics and outcomes of COVID-19 infection in 45 patients with breast cancer: a multi-center retrospective study in Hubei, China[J]. Breast, 2021, 59: 102-109.
doi: 10.1016/j.breast.2021.06.006 |
[39] |
ZHOU Y D,, HOU Y,, SHEN J Y, et al.Network-based drug repurposing for novel coronavirus 2019-nCoV/SARS-CoV-2[J]. Cell Discov, 2020, 6: 14.
doi: 10.1038/s41421-020-0153-3 |
[40] |
MARTIN W R,, CHENG F X.Repurposing of FDA-approved toremifene to treat COVID-19 by blocking the spike glycoprotein and NSP14 of SARS-CoV-2[J]. J Proteome Res, 2020, 19(11): 4670-4677.
doi: 10.1021/acs.jproteome.0c00397 |
[41] |
ZU S L,, LUO D,, LI L L, et al.Tamoxifen and clomiphene inhibit SARS-CoV-2 infection by suppressing viral entry[J]. Signal Transduct Target Ther, 2021, 6(1): 435.
doi: 10.1038/s41392-021-00853-4 |
[42] |
HU S Y,, YIN F Y,, NIE L T, et al.Estrogen and estrogen receptor modulators: potential therapeutic strategies for COVID-19 and breast cancer[J]. Front Endocrinol (Lausanne), 2022, 13: 829879.
doi: 10.3389/fendo.2022.829879 |
[43] | OTTAVIANO M,, CURVIETTO M,, RESCIGNO P, et al.Impact of COVID-19 outbreak on cancer immunotherapy in Italy: a survey of young oncologists[J]. J Immunother Cancer, 2020, 8(2): e001154. |
[44] | Recommendations for prioritization,treatment and triage of breast cancer patients during the covid-19 pandemic[EB/OL].American College of Surgeons Available at https://www.facs.org/qualityprograms/cancer/executive-summary. Accessed March 26, 2020. |
[45] | DE AZAMBUJA E,, TRAPANI D,, LOIBL S, et al.ESMO Management and treatment adapted recommendations in the COVID-19 era: breast cancer[J]. ESMO Open, 2020, 5(Suppl 3): e000793. |
[46] |
PINATO D J,, TABERNERO J,, BOWER M, et al.Prevalence and impact of COVID-19 sequelae on treatment and survival of patients with cancer who recovered from SARS-CoV-2 infection: evidence from the OnCovid retrospective, multicentre registry study[J]. Lancet Oncol, 2021, 22(12): 1669-1680.
doi: 10.1016/S1470-2045(21)00573-8 |
[47] |
ZHANG H Y,, WANG L W,, CHEN Y Y, et al.Outcomes of novel coronavirus disease 2019 (COVID-19) infection in 107 patients with cancer from Wuhan, China[J]. Cancer, 2020, 126(17): 4023-4031.
doi: 10.1002/cncr.33042 |
[48] |
LEE L Y W,, CAZIER J B,, STARKEY T, et al.COVID-19 prevalence and mortality in patients with cancer and the effect of primary tumour subtype and patient demographics: a prospective cohort study[J]. Lancet Oncol, 2020, 21(10): 1309-1316.
doi: 10.1016/S1470-2045(20)30442-3 |
[49] |
LIU H Q,, YANG D,, CHEN X Y, et al.The effect of anticancer treatment on cancer patients with COVID-19: a systematic review and meta-analysis[J]. Cancer Med, 2021, 10(3): 1043-1056.
doi: 10.1002/cam4.3692 |
[50] | VÁRNAI C,, PALLES C,, ARNOLD R, et al.Mortality among adults with cancer undergoing chemotherapy or immunotherapy and infected with COVID-19[J]. JAMA Netw Open, 2022, 5(2): e220130. |
[51] |
MUKHERJI R,, MARSHALL J L.Lessons learned in managing patients with colorectal cancer during the COVID-19 pandemic[J]. Curr Treat Options Oncol, 2021, 22(10): 93.
doi: 10.1007/s11864-021-00888-3 |
[52] |
GARCÍA-SUÁREZ J,, DE LA CRUZ J,, CEDILLO Á, et al.Impact of hematologic malignancy and type of cancer therapy on COVID-19 severity and mortality: lessons from a large population-based registry study[J]. J Hematol Oncol, 2020, 13(1): 133.
doi: 10.1186/s13045-020-00970-7 |
[53] |
DULÉRY R,, LAMURE S,, DELORD M, et al.Prolonged in-hospital stay and higher mortality after Covid-19 among patients with non-Hodgkin lymphoma treated with B-cell depleting immunotherapy[J]. Am J Hematol, 2021, 96(8): 934-944.
doi: 10.1002/ajh.26209 |
[54] | GHIONE P,, GU J J,, ATTWOOD K, et al.Impaired humoral responses to COVID-19 vaccination in patients with lymphoma receiving B-cell-directed therapies[J]. Blood, 2021, 138(9): 811-814. |
[55] |
TREON S P,, CASTILLO J J,, SKARBNIK A P, et al.he BTK inhibitor ibrutinib may protect against pulmonary injury in COVID-19-infected patients. Blood. 2020; 135(21): 1912-1915[J].Blood, 2021, 137(11): 1561.
doi: 10.1182/blood.2021010938 |
[56] |
SCARFÒ L,, CHATZIKONSTANTINOU T,, RIGOLIN G M, et al.COVID-19 severity and mortality in patients with chronic lymphocytic leukemia: a joint study by ERIC, the European Research Initiative on CLL, and CLL Campus[J]. Leukemia, 2020, 34(9): 2354-2363.
doi: 10.1038/s41375-020-0959-x |
[57] |
GIESEN N,, SPRUTE R,, RÜTHRICH M, et al.2021 update of the AGIHO guideline on evidence-based management of COVID-19 in patients with cancer regarding diagnostics, viral shedding, vaccination and therapy[J]. Eur J Cancer, 2021, 147: 154-160.
doi: 10.1016/j.ejca.2021.01.033 |
[58] |
LEE L Y,, CAZIER J B,, ANGELIS V, et al.COVID-19 mortality in patients with cancer on chemotherapy or other anticancer treatments: a prospective cohort study[J]. Lancet, 2020, 395(10241): 1919-1926.
doi: 10.1016/S0140-6736(20)31173-9 |
[59] |
KUDERER N M,, CHOUEIRI T K,, SHAH D P, et al.Clinical impact of COVID-19 on patients with cancer (CCC19): a cohort study[J]. Lancet, 2020, 395(10241): 1907-1918.
doi: 10.1016/S0140-6736(20)31187-9 |
[60] |
SATHIAN B,, ASIM M,, BANERJEE I, et al.Impact of COVID-19 on clinical trials and clinical research: a systematic review[J]. Nepal J Epidemiol, 2020, 10(3): 878-887.
doi: 10.3126/nje.v10i3.31622 |
[61] |
DE PAULA B H R,, ARAÚJO I,, BANDEIRA L, et al.Recommendations from national regulatory agencies for ongoing cancer trials during the COVID-19 pandemic[J]. Lancet Oncol, 2020, 21(5): 624-627.
doi: 10.1016/S1470-2045(20)30226-6 |
[62] | 李丹,, 刘晓红,, 卢冬青, 等.新型冠状病毒肺炎疫情下抗肿瘤药物临床试验受试者的随访分析[J]. 中国新药杂志, 2021, 30(12): 1099-1102. |
LI D,, LIU X H,, LU D Q, et al.Analysis of follow-up for subjects of anti-cancer clinical trials under COVID-19[J]. Chin J New Drugs, 2021, 30(12): 1099-1102. | |
[63] | 刘小保,, 高素彬,, 衡建福, 等.新冠肺炎疫情下抗肿瘤药物临床试验现状与紧急应对策略[J]. 肿瘤药学, 2020, 10(S1): 2-10. |
LIU X B,, GAO S B,, HENG J F, et al.The Current situation of anti-cancer drug clinical trial during the epidemic of COVID-19 and the emergency response strategies[J]. Anti Tumor Pharm, 2020, 10(S1): 2-10. | |
[64] | 刘丹,, 曾圣雅,, 邓璠, 等.临床科研项目知情同意过程存在问题及解决途径[J]. 中国医学伦理学, 2018, 31(6): 732-735. |
LIU D,, ZENG S Y,, DENG F, et al.Existing problems and solution of informed consent in clinical research[J]. Chin Med Ethics, 2018, 31(6): 732-735. | |
[65] |
GIESEN N,, SPRUTE R,, RÜTHRICH M, et al.2021 update of the AGIHO guideline on evidence-based management of COVID-19 in patients with cancer regarding diagnostics, viral shedding, vaccination and therapy[J]. Eur J Cancer, 2021, 147: 154-160.
doi: 10.1016/j.ejca.2021.01.033 |
[1] | JIANG Jinling, ZHOU Chenfei, XI Wenqi, SHI Min, GEN Mei, ZHAO Liqin, CAI Qu, JIANG Jinsong, ZHANG Jun. Optimization of 5-FU metronomic chemotherapy strategy and regulation of the immune microenvironment in gastric cancer: an in vivo study [J]. China Oncology, 2022, 32(7): 596-605. |
[2] | YU Silai, NI Jianjiao, ZHU Zhengfei. Treatment of unresectable locally advanced non-small cell lung cancer in the era of immunotherapy: status and prospects [J]. China Oncology, 2022, 32(6): 487-498. |
[3] | ZHU Jun, WU Xiaohua. Leading research progress and prospect of gynecological oncology in 2020 [J]. China Oncology, 2021, 31(4): 250-256. |
[4] | CAI Shumo, TANG Jie, HUANG Xiao, HUANG Xiaowei, LIU Suping, KE Guihao, ZHENG Zhong, CHENG Xi, TANG Meiqin. Three-step chemotherapy treatment for platinum-sensitive recurrent ovarian cancer: a review of 20 cases [J]. China Oncology, 2021, 31(4): 330-334. |
[5] | HU Xi’e , YANG Zhenyu , XUE Jingyi , YANG Ping , PENG Shujia , YUAN Lijuan , BAO Guoqiang . Research progress of single-cell sequencing in neoadjuvant chemotherapy for triple-negative breast cancer [J]. China Oncology, 2021, 31(3): 221-226. |
[6] | HE Hesheng , YANG Yuqiong , LIU Yinhua , JIN Xiaoke , XU Youhai , YAO Junping , LIU Shanhao , YAN Jiawei , HUANG Dongping . Characteristic analysis of peripheral T-cell lymphoma associated with autoimmune hemolytic anemia [J]. China Oncology, 2021, 31(2): 121-125. |
[7] | LI Lei , WANG Zhi , YOU Chunyuan . The relapse of primary cardiac high-grade B-cell lymphoma after remission: a case report [J]. China Oncology, 2021, 31(2): 156-160. |
[8] | LI Panpan, ZHANG Zhuo. Analysis of prognostic factors in 42 cases of primary central nervous system lymphoma [J]. China Oncology, 2021, 31(12): 1194-1201. |
[9] | YU Yi, CONG Qing, XU Congjian, JIANG Wei. The effect of PAFR on cisplatin sensitivity in ovarian cancer cells and its mechanism [J]. China Oncology, 2021, 31(11): 1063-1071. |
[10] | LIU Jiawei, LI Dan, ZHAI Qing. Risk factors analysis of liver injury induced by chemotherapy in patients with breast cancer [J]. China Oncology, 2021, 31(1): 52-62. |
[11] | YAN Fang, YING Mingzhen, CHEN Longpei, FU Qiang. Clinical observation of albumin-bound paclitaxel plus nedaplatin as first-line treatment in advanced esophageal squamous cell carcinoma patients [J]. China Oncology, 2020, 30(8): 632-635. |
[12] | ZHANG Xiaomeng , MA Ningyi , ZHU Hongcheng , AI Dashan , REN Zhigang . Efficacy and prognostic factors of adjuvant radiotherapy combined with chemotherapy in patients with pancreatic cancer [J]. China Oncology, 2020, 30(7): 519-524. |
[13] | SHI Zhiqiang , QIU Pengfei , LIU Yanbing , ZHAO Tong , SUN Xiao , CHEN Peng , WANG Chunjian , ZHANG Zhaopeng , CONG Binbin , WANG Yongsheng . Selective elimination of axillary surgery staging after neoadjuvant chemotherapy for HER2 positive and triple-negative breast cancer [J]. China Oncology, 2020, 30(3): 186-191. |
[14] | NING Zhouyu, HUA Yongqiang, XU Litao, ZHUANG Liping, FENG Lanyun, CHEN Hao, WANG Peng, SHEN Yehua, LIN Junhua, CHEN Zhen, MENG Zhiqiang. Efficacy and safety of nab-paclitaxel plus gemcitabine in the treatment of advanced pancreatic cancer by transcatheter arterial chemotherapy: a retrospective study [J]. China Oncology, 2020, 30(2): 128-134. |
[15] | CHENG Qi, YI Xiaofang. Research progress on ferroptosis in drug resistance of tumor [J]. China Oncology, 2020, 30(2): 148-153. |
Viewed | ||||||
Full text |
|
|||||
Abstract |
|
|||||
沪ICP备12009617
Powered by Beijing Magtech Co. Ltd