New progress and development trend of surgical treatment for gastric cancer

doi:10.19401/j.cnki.1007-3639.2024.03.002

Abstract

Abstract:

Gastric cancer poses a serious threat to the health of people. Despite the continuous breakthroughs in the development of new drugs such as chemotherapy, targeted therapy and immunotherapy in recent years, radical surgery remains the cornerstone in the treatment of gastric cancer. With the establishment of standard gastric cancer surgery, the advancement of minimally invasive surgical techniques represented by laparoscopy, the determination of perioperative comprehensive treatment of advanced gastric cancer and the formation and initial practice of precise surgical concepts for gastric cancer, the progress of surgical treatment for gastric cancer is advancing by leaps and bounds. The concepts of individualized and optimal treatment are gradually taking root. Safety, effectiveness, precision and minimally invasive approaches have always been the inherent laws of discipline development firmly grasped by gastric cancer surgeons. In order to facilitate better growth for young doctors, the author summarized the latest developments in the diagnosis and treatment of gastric cancer and looked ahead to future trend.

Key words: Gastric cancer, Surgical treatment, Progress, Trend

CLC Number:

R735.2

WANG Xuefei, ZHOU Peng, TANG Zhaoqing. New progress and development trend of surgical treatment for gastric cancer[J]. China Oncology, 2024, 34(3): 250-258.

Figures/Tables 1

References 55

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Surgical scope	Case characteristic	Study name	Study design	Major investigator	Case N	Primary study endpoint
Distal stomach	Early gastric cancer	KLASS-01^[16]	Stage Ⅲ RCT	Woo Jin Hyung (Yonsei University)	1 416	5-year disease-free survival rate
		JCOG0912^[17]	Stage Ⅲ RCT	Hitoshi Katai (National Cancer CenterJapan)	921	Recurrence-free survival
	Advanced gastric carcinoma	CLASS-01^[18]	Stage Ⅲ RCT	LI Guoxin (Nanfang Hospital, Southern Medical University)	1 039	3-year recurrence-free survival rate
Whole stomach	Early gastric cancer	CLASS-02^[21]	Stage Ⅲ RCT	SUN Yihong (Zhongshan University, Fudan University)	227	Postoperative complication rate and mortality
		KLASS-03^[19]	Stage Ⅱ single-arm study	Gyu Seok Cho (Soonchunhyang University)	160	Postoperative complication rate and mortality
		JCOG1401^[20]	Stage Ⅱ single-arm study	Hitoshi Katai (National Cancer CenterJapan)	195	Postoperative complication rate and mortality
	Advanced gastric carcinoma	CLASS-07	Stage Ⅲ RCT	SUN Yihong (Zhongshan University, Fudan University)	1 316	OS
		KLASS-06	Stage Ⅲ RCT	Woo Jin Hyung (Yonsei University)	772	3-year recurrence-free survival rate