Potential of targeting TROP2 in the treatment of pancreatic cancer

doi:10.19401/j.cnki.1007-3639.2022.03.010

Abstract

Abstract:

Pancreatic cancer is a malignant tumor with high incidence, rapid progression and low survival rate. It is in urgent need of new targets for precise treatment or improvement of prognosis. In recent years, it has been found that trophoblast cell surface antigen 2 (TROP2) is highly expressed in a variety of malignant tumors and participates in the progress of proliferation, migration and adhesion of malignant tumor cells through cell surface receptor signals. In this paper, the expression of TROP2 in pancreatic cancer, the signaling pathway involved in the mediation of TROP2 and the research progress of antitumor drugs targeting TROP2 were summarized, which provided some references for the mechanism of targeting TROP2 in the treatment of pancreatic cancer and the improvement of prognosis of patients.

Key words: Pancreatic cancer, Trophoblast cell surface antigen 2, Targeted therapy, Research progress

CLC Number:

R735.9

LI Yujie, CHEN Hao. Potential of targeting TROP2 in the treatment of pancreatic cancer[J]. China Oncology, 2022, 32(3): 268-273.

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