Abstract:

Background and purpose: Colorectal cancer is a kind of common digestive malignancies, which seriously threaten the human health. Although modern diagnostic and treatment technology has developed rapidly, the incidence and mortality of colorectal cancer continue to show an increasing tendency in recent years, and early diagnosis and prevention of colorectal cancer liver metastases are important to increase the survival rate of patients and to improve the prognosis. P-selectin and L-selectin is attracting much attention in cancer research field recently, and the change of their expression and mediated adhesion play an important role in tumor cell metastasis, but their relationship between the occurrence and clinical stage of colorectal cancer rarely reported. This study aimed to explore whether the serum P-selectin and L-selectin levels of colorectal cancer patients were correlated with clinical and pathological features and the situation before and after surgery. Methods: A total number of 132 cases of colorectal cancer patients and 100 healthy subjects with gender and age-matched were enrolled. Enzyme-linked immunosorbent assay (ELISA) was used to detect serum P-selectin and L-selectin concentrations in 132 cases before and after surgery, 100 healthy subjects were enrolled as the control group, the P-selectin and L-selectin levels were analyzed combined with the clinical and pathological features. Results: Serum P-selectin and L-selectin levels in patients with colorectal cancer before surgery were significantly higher than those in the healthy control group (75.2±13.3 vs 26.6±9.6, 89.2±12.7 vs 33.9±8.3, P<0.05) ; Compared with the patients before surgery, 1 week after surgery, the P-selectin and L-selectin levels were not significantly decreased (63.8±11.1 vs 75.2±13.3, 71.5±10.9 vs 89.2±12.7, P>0.05); however, significantly decreased after 3 months (34.8±10.4 vs 75.2±13.3, 40.1±9.5 vs 89.2±12.7, P<0.01); This paper studied patients with colorectal cancer, the higher clinical stage, higher P-selectin and L-selectin levels, and their expression levels with tumor invasion depth, Dukes stage, histological grade and lymph node metastasis were related, but were not correlated with age, gender and tumor site. Meanwhile, P-selectin and L-selectin levels were not significantly correlated in the same serum of patients with colorectal cancer (r=4.114, P>0.05). Conclusion: Serum P-selectin and L-selectin levels to some extent reflect the invasion of colorectal cancer, the degree of infiltration and lymph node metastasis, and which can be an important indicator in the development and prognosis of colorectal cancer.

Key words: Colorectal cancer, P-selectin, L-selectin