China Oncology ›› 2020, Vol. 30 ›› Issue (4): 246-253.doi: 10.19401/j.cnki.1007-3639.2020.04.002

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Survival report of 13.7 thousand surgical colorectal cancer patients from a large single hospital-based cancer registry

ZHOU Changming 1 , GUO Tianan 2 , MO Miao 1 , YUAN Jing 1 , SHEN Jie 1 , WANG Zezhou 1 , HUANG Dan 3 , ZHU Ji 4 , LI Xinxiang 2 , CAI Guoxiang 2 , XU Ye 2 , CAI Sanjun 2 , ZHENG Ying 1   

  1. 1. Department of Cancer Prevention, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China; 2. Department of Colorectal Surgery, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China; 3. Department of Pathology, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China; 4. Department of Radiotherapy, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China
  • Online:2020-04-30 Published:2020-05-11
  • Contact: ZHENG Ying E-mail: zhengying@fudan.edu.cn

Abstract:  Background and purpose: The study analyzed 1-, 3- and 5-year observed overall survival (OS) and disease-free survival (DFS), providing real world evidence of long-term survival among Chinese surgical colorectal cancer patients. Methods: A total of 13 721 colorectal cancer patients undergoing surgery in Fudan University Shanghai Cancer Center (FUSCC) from Jan. 1, 2008 to Dec. 31, 2017 were included in the analysis. Medical records review, telephone visits and death registry data linkage were carried out for collecting endpoint data. The last follow-up date was Nov. 30, 2019. Kaplan-Meier method was used to evaluate the 1-, 3-, and 5-year OS and DFS, and data were stratified by age group, gender, staging, calendar period, pathological characteristics and treatment approaches. Results: With a median follow-up time of 54.03 months, the 5-year OS of all patients and DFS of 0-Ⅲ stage surgical colorectal cancer patients were 73.87% and 72.25%, respectively. The 5-year OS of stage 0-Ⅰ,Ⅱ,Ⅲ and Ⅳ colorectal cancer patients were 91.92%, 87.15%, 70.49% and 27.70%, respectively. The OS of patients aged less than 45 years was 74.93%, poorer than 45-64 and 65-74 age category. There were significant difference in OS and DFS among different histology types, differentiation, extermural vascular invasion, perineural invasion and circumferential radial margin. Conclusion: It is the first single institutional long term survival report of over 10 thousand colorectal cancer patients. Young patients aged less than 45 years had a poor prognosis. Staging is an important modifiable factor, which implies that enhancing screening and early diagnosis has important meaning to further improve the patients’ survival.

Key words: Colorectal cancer, Overall survival, Disease-free survival, Hospital-based registry