Abstract: Breast cancer can be classified into 4 intrinsic subtypes by gene expression profiling: basal-like, HER-2-positive, Luminal A and Luminal B. Although Luminal cancers share similarities, the studies showed that Luminal A and B breast cancers should be perceived as distinct entities. Luminal B breast cancer has lower expression of hormone receptors, and it also exhibits worse prognosis and has a distinct profile of response to chemotherapy and endocrine therapy. This review presented the available clinical evidence for chemotherapy and endocrine therapy patterns of response, and potential targets for treatment.

Key words: Breast cancer, Luminal B subtype, Treatment, Target