Abstract: Background and purpose: This study aimed to estimate the spike-effect of domestic nanometer activated carbon on the radical operation for early stage low-lying rectal cancer. Methods: From Jan. 2013 to Dec. 2015, 66 patients with early stage low-lying rectal cancer were randomly divided into two groups: study group and control group. The patients of study group were treated with injection of carbon nanoparticles suspension in tumor vicinity before the operation. This study compared the total number of lymph node, the scale percentage of micro lymph node between two groups. SLNs of study group were obtained for pathological examination. Results: The differences in the total number of lymph node and the scale percentage of micro lymph node between two groups were statistically significant (P<0.05). The diagnostic sensitivity and false-negative rate were 90.9% and 3.8%, respectively. Conclusion: Local injection of nanometer activated carbon around the tumor is important to the metastasis lymph node resection, especially to SLN biopsy in the radical operation for rectal cancer.

Key words: Rectal cancer, Carbon nanoparticles, Sentinel lymph node