关键词: 胰腺癌, 灌注CT, 生物学行为

Abstract:         Background and purpose: The prognosis of pancreatic cancer is poor. This study aimed to evaluate the value of pancreatic CT perfusion on biological behavior assessment in pancreatic cancer. Methods: This study collected 78 cases of pancreatic cancer which diagnosed by the method of pancreatic CT perfusion, and detected the differences of the values of blood flow (BF), blood volume (BV), permeability (per), peak value (PE) and time to peak (TTP) between normal pancreatic tissues and tumor tissues. Combined with clinical and pathological data. Besides, this study evaluated the relationship between perfusion parameters of tumor tissues and tumor size, lymph node metastasis, distant metastasis, preoperative serum CA199 level, Ki-67, p53, CEA, CA199, CD34 expression of tumor tissues. Results: The values of BF, BV, per and PE in pancreatic tumor tissue were significantly lower than those in normal pancreatic tissue. The BF values of cases with high levels of serum CA199 and with CA199 positively expressed tissues were significantly higher than those with negative expression. The PE values of cases with positive tissue expression of Ki-67 were significantly higher than those with negative expression. The TTP values of cases with positive tissue expression of CEA were significantly lower than those with negative expression. The per values of well differentiated cases was significantly higher than those of moderately/poorly differentiated cases. Conclusion: CT perfusion may have its value on assessment of tumor biological behavior in pancreatic cancer.

Key words: Pancreatic Cancer, CT perfusion, Biological behavior