China Oncology ›› 2023, Vol. 33 ›› Issue (6): 605-612.doi: 10.19401/j.cnki.1007-3639.2023.06.008
• Article • Previous Articles Next Articles
Received:
2023-03-31
Revised:
2023-04-16
Online:
2023-06-30
Published:
2023-07-26
CLC Number:
ZOU Ting, LIU Xiaowen. Analysis of efficacy of hepatectomy and prognostic risk factors in patients with gastric cancer with synchronous liver metastasis[J]. China Oncology, 2023, 33(6): 605-612.
Tab.1
Clinicopathological data of 79 patients with gastric cancer with synchronous liver metastases"
Factor | n (%) | Factor | n (%) | |
---|---|---|---|---|
Gender | Hepatic tumor distribution | |||
Male | 67 (85) | Unilateral | 50 (63) | |
Female | 12 (15) | Bilateral | 28 (36) | |
Age/year | NA | 1 (1) | ||
≤60 | 31 (39) | Metastatic tumor number | ||
>60 | 48 (61) | Single | 41 (52) | |
Primary tumor size D/cm | Multiple | 37 (47) | ||
≤5 | 37 (47) | NA | 1 (1) | |
>5 | 37 (47) | Hepatectomy | ||
NA | 5 (6) | Yes | 34 (43) | |
Location | No | 45 (57) | ||
Upper-middle | 37 (47) | Peritoneal metastasis | ||
Lower | 39 (49) | Yes | 0 (0) | |
NA | 3 (4) | No | 79 (100) | |
Depth of invasion | Serum AFP level at diagnosis | |||
T1-2 | 7 (9) | Normal | 50 (63) | |
T3-4 | 42 (53) | Elevated | 7 (9) | |
NA | 30 (38) | NA | 22 (28) | |
Lymph node metastasis | Serum CEA level at diagnosis | |||
N0-1 | 14 (18) | Normal | 32 (40) | |
N2-3 | 35 (44) | Elevated | 25 (32) | |
NA | 30 (38) | NA | 22 (28) | |
Differentiated degree | Synchronous liver metastases | |||
Well/moderate | 25 (32) | Yes | 79 (100) | |
Poor | 30 (38) | No | 0 (0) | |
NA | 24 (30) | |||
Metastatic tumor size D/cm | ||||
≤3 | 41 (52) | |||
>3 | 7 (9) | |||
NA | 31 (39) |
Tab. 2
Univariate and multivariate analysis of OS in patients with gastric cancer with synchronous liver metastases"
Data | Univariate analysis | Multivariate analysis | |||
---|---|---|---|---|---|
P value | HR | 95% CI | P value | ||
Gender | 0.992 | ||||
Age/year | 0.879 | ||||
Primary tumor size D/cm | 0.046 | 0.662 | 0.164-2.666 | 0.562 | |
Location | 0.136 | ||||
Depth of invasion | 0.087 | ||||
Number of lymph nodes | 0.087 | 2.055 | 0.359-11.746 | 0.418 | |
Differentiated degree | 0.001 | 0.185 | 0.034-1.011 | 0.052 | |
Metastatic tumor size D/cm | 0.360 | 0.593 | 0.092-3.812 | 0.582 | |
Hepatic tumor distribution | 0.038 | 37.253 | 2.577-538.447 | 0.008 | |
Metastatic tumor number | 0.456 | 1.790 | 0.303-10.581 | 0.521 | |
Hepatectomy | 0.000 | 0.149 | 0.023-0.948 | 0.044 | |
Serum AFP level at diagnosis | 0.000 | 8.554 | 0.851-86.032 | 0.068 | |
Serum CEA level at diagnosis | 0.149 |
[1] |
SUNG H, FERLAY J, SIEGEL R L, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J]. CA Cancer J Clin, 2021, 71(3): 209-249.
doi: 10.3322/caac.v71.3 |
[2] |
FERLAY J, STELIAROVA-FOUCHER E, LORTET-TIEULENT J, et al. Cancer incidence and mortality patterns in Europe: estimates for 40 countries in 2012[J]. Eur J Cancer, 2013, 49(6): 1374-1403.
doi: 10.1016/j.ejca.2012.12.027 pmid: 23485231 |
[3] |
SHAH M A, KELSEN D P. Gastric cancer: a primer on the epidemiology and biology of the disease and an overview of the medical management of advanced disease[J]. J Natl Compr Canc Netw, 2010, 8(4): 437-447.
doi: 10.6004/jnccn.2010.0033 |
[4] |
CONDE MONROY D, IBAÑEZ-PINILLA M, SABOGAL J C, et al. Survival outcomes of hepatectomy in gastric cancer liver metastasis: a systematic review and meta-analysis[J]. J Clin Med, 2023, 12(2): 704.
doi: 10.3390/jcm12020704 |
[5] |
GARANCINI M, UGGERI F, DEGRATE L, et al. Surgical treatment of liver metastases of gastric cancer: is local treatment in a systemic disease worthwhile?[J]. HPB (Oxford), 2012, 14(3): 209-215.
doi: 10.1111/j.1477-2574.2011.00428.x |
[6] |
MIKI Y, FUJITANI K, HIRAO M, et al. Significance of surgical treatment of liver metastases from gastric cancer[J]. Anticancer Res, 2012, 32(2): 665-670.
pmid: 22287760 |
[7] |
ROMANO F, GARANCINI M, UGGERI F, et al. Surgical treatment of liver metastases of gastric cancer: state of the art[J]. World J Surg Oncol, 2012, 10: 157.
doi: 10.1186/1477-7819-10-157 pmid: 22862882 |
[8] |
CHEN L, SONG M Q, LIN H Z, et al. Chemotherapy and resection for gastric cancer with synchronous liver metastases[J]. World J Gastroenterol, 2013, 19(13): 2097-2103.
doi: 10.3748/wjg.v19.i13.2097 |
[9] |
FUJITANI K, YANG H K, MIZUSAWA J, et al. Gastrectomy plus chemotherapy versus chemotherapy alone for advanced gastric cancer with a single non-curable factor (REGATTA): a phase 3, randomised controlled trial[J]. Lancet Oncol, 2016, 17(3): 309-318.
doi: S1470-2045(15)00553-7 pmid: 26822397 |
[10] |
GRANIERI S, ALTOMARE M, BRUNO F, et al. Surgical treatment of gastric cancer liver metastases: systematic review and meta-analysis of long-term outcomes and prognostic factors[J]. Crit Rev Oncol Hematol, 2021, 163: 103313.
doi: 10.1016/j.critrevonc.2021.103313 |
[11] | MINCIUNA C E, TUDOR S, MICU A, et al. Safety and efficacy of simultaneous resection of gastric carcinoma and synchronous liver metastasis-a western center experience[J]. Medicina (Kaunas), 2022, 58(12): 1802. |
[12] |
YAMAGUCHI T, TAKASHIMA A, NAGASHIMA K, et al. Evaluating the efficacy of post-operative chemotherapy after curative resection of stage Ⅳ gastric cancer with synchronous oligo metastasis: a multicenter retrospective study[J]. Gastric Cancer, 2023, 26(2): 307-316.
doi: 10.1007/s10120-023-01363-8 |
[13] |
CUI J K, LIU M, SHANG X K. Hepatectomy for liver metastasis of gastric cancer: a meta-analysis[J]. Surg Innov, 2019, 26(6): 692-697.
doi: 10.1177/1553350619856491 |
[14] |
OCHIAI T, SASAKO M, MIZUNO S, et al. Hepatic resection for metastatic tumours from gastric cancer: analysis of prognostic factors[J]. Br J Surg, 1994, 81(8): 1175-1178.
doi: 10.1002/bjs.1800810832 |
[15] |
MARTE G, TUFO A, STECCANELLA F, et al. Efficacy of surgery for the treatment of gastric cancer liver metastases: a systematic review of the literature and meta-analysis of prognostic factors[J]. J Clin Med, 2021, 10(5): 1141.
doi: 10.3390/jcm10051141 |
[16] |
OHKURA Y, SHINOHARA H, HARUTA S, et al. Hepatectomy offers superior survival compared with non-surgical treatment for≤3 metastatic tumors with diameters < 3 cm from gastric cancer: a retrospective study[J]. World J Surg, 2015, 39(11): 2757-2763.
doi: 10.1007/s00268-015-3151-0 |
[17] |
OKI E, TOKUNAGA S, EMI Y, et al. Surgical treatment of liver metastasis of gastric cancer: a retrospective multicenter cohort study (KSCC1302)[J]. Gastric Cancer, 2016, 19(3): 968-976.
doi: 10.1007/s10120-015-0530-z pmid: 26260876 |
[18] |
WANG Y N, SHEN K T, LING J Q, et al. Prognostic analysis of combined curative resection of the stomach and liver lesions in 30 gastric cancer patients with synchronous liver metastases[J]. BMC Surg, 2012, 12: 20.
doi: 10.1186/1471-2482-12-20 |
[19] |
KINOSHITA T, KINOSHITA T, SAIURA A, et al. Multicentre analysis of long-term outcome after surgical resection for gastric cancer liver metastases[J]. Br J Surg, 2015, 102(1): 102-107.
doi: 10.1002/bjs.9684 pmid: 25389030 |
[20] |
TIBERIO G A, MINISTRINI S, GARDINI A, et al. Factors influencing survival after hepatectomy for metastases from gastric cancer[J]. Eur J Surg Oncol, 2016, 42(8): 1229-1235.
doi: 10.1016/j.ejso.2016.03.030 pmid: 27134189 |
[21] |
UGGERI F, RIPAMONTI L, PINOTTI E, et al. Is there a role for treatment-oriented surgery in liver metastases from gastric cancer?[J]. World J Clin Oncol, 2020, 11(7): 477-494.
doi: 10.5306/wjco.v11.i7.477 pmid: 32821653 |
[22] |
CHEN J, TANG Z, DONG X, et al. Radiofrequency ablation for liver metastasis from gastric cancer[J]. Eur J Surg Oncol, 2013, 39(7): 701-706.
doi: 10.1016/j.ejso.2013.03.023 pmid: 23597495 |
[23] | ZHANG K C, CHEN L. Chinese consensus on the diagnosis and treatment of gastric cancer with liver metastases[J]. Ther Adv Med Oncol, 2020, 12: 1758835920904803. |
[24] |
KATAOKA K, KINOSHITA T, MOEHLER M, et al. Current management of liver metastases from gastric cancer: what is common practice? New challenge of EORTC and JCOG[J]. Gastric Cancer, 2017, 20(5): 904-912.
doi: 10.1007/s10120-017-0696-7 pmid: 28150070 |
[25] |
VIGANÒ L, VELLONE M, FERRERO A, et al. Liver resection for gastric cancer metastases[J]. Hepato-gastroenterology, 2013, 60(123): 557-562.
pmid: 23635434 |
[26] |
YUKAMI H, KAWAZOE A, LIN Y T, et al. Updated efficacy outcomes of anti-PD-1 antibodies plus multikinase inhibitors for patients with advanced gastric cancer with or without liver metastases in clinical trials[J]. Clin Cancer Res, 2022, 28(16): 3480-3488.
doi: 10.1158/1078-0432.CCR-22-0630 pmid: 35679062 |
[1] | DU Shuxiang, ZHAO Yingzhi, ZHANG Xuetao, WANG Tao, LUO Jingyu, ZHANG Wei, WU Gang. Analysis of group 12a lymph node metastasis at different sites of gastric adenocarcinoma and its risk factors [J]. China Oncology, 2023, 33(6): 597-604. |
[2] | JIANG Jinling, ZHOU Chenfei, WANG Chao, ZHAO Liqin, WU Junwei, ZHANG Jun. Advanced progress in research and diagnosis of gastric cancer in 2022 [J]. China Oncology, 2023, 33(4): 303-314. |
[3] | XIAO Lanshu, PAN Liudi, LIU Yi, WANG Jie, CHEN Hui. LncRNA DLEU7-AS1 contributes to proliferation and migration of gastric cancer by regulating MSN transcription [J]. China Oncology, 2023, 33(4): 327-341. |
[4] | PENG Jin, WANG Weining, TAN Zhi, YE Guannan, ZHOU Zhen. The mechanism of m6Am-modifying enzyme PCIF1 regulating target gene ACOT8 in gastric cancer progression [J]. China Oncology, 2023, 33(4): 368-376. |
[5] | LIU Yang, HU Yiyang, LIU Yueping, NIU Shuyao, DING Pingan, TIAN Yuan, GUO Honghai, YANG Peigang, ZHANG Ze, ZHENG Tao, TAN Bibo, FAN Liqiao, LI Yong, ZHAO Qun. The value of artificial intelligence-assisted technology in HER2 assessmentof gastric cancer patients receiving neoadjuvant chemotherapy [J]. China Oncology, 2023, 33(4): 377-387. |
[6] | CHEN Xinning, JIANG Huiqin, YANG Yihui, YU Qian, ZHANG Chunyan, WANG Beili, PAN Baishen, GUO Wei. Expression of plasma methylated Septin9 gene and its clinical significance in patients with gastric cancer [J]. China Oncology, 2023, 33(2): 162-167. |
[7] | CAI Gang, WANG Shubei, CHEN Jiayi. The current data and challenge of radiotherapy in the case management of gastric cancer [J]. China Oncology, 2022, 32(7): 581-587. |
[8] | CAO Mengxuan, HU Can, ZHANG Yanqiang, HUANG Ling, DU Yian, YU Pengcheng, ZHANG Ruolan, XU Zhiyuan, CHENG Xiangdong. Analysis of risk factors of early recurrence and metastasis after radical resection of gastric cancer [J]. China Oncology, 2022, 32(7): 588-595. |
[9] | JIANG Jinling, ZHOU Chenfei, XI Wenqi, SHI Min, GEN Mei, ZHAO Liqin, CAI Qu, JIANG Jinsong, ZHANG Jun. Optimization of 5-FU metronomic chemotherapy strategy and regulation of the immune microenvironment in gastric cancer: an in vivo study [J]. China Oncology, 2022, 32(7): 596-605. |
[10] | ZHANG Xuecheng , GUAN Xiaohui . Circ_0007142 accelerates epithelial-mesenchymal transition and invasion of gastric cancer cells through sponging miR-647 and regulating CCR8 gene [J]. China Oncology, 2021, 31(8): 714-724. |
[11] | GONG Chao , CHEN Kui , ZHANG Dekun , XIE Jingfeng , WU Fanghua , HUANG Yudian , XUE Yuqin , WANG Liqun . Construction of a prediction model for metastasis in gastric cancer based on the weighted gene co-expression network analysis [J]. China Oncology, 2021, 31(8): 746-753. |
[12] | ZHENG Peiming , LI Junmeng , ZHANG Peng , GAO Lan . Exosomal transfer of macrophage-derived miR-223 confers oxaliplatin resistance in gastric cancer [J]. China Oncology, 2021, 31(5): 368-378. |
[13] | LIU Bin , ZHENG Pengyuan , MI Yang , REN Feifei , GAO Shuang , LIU Chuan , LI Fazhan . Expression of LRP8 in gastric cancer and its significance in tumorigenesis [J]. China Oncology, 2021, 31(4): 285-293. |
[14] | DING Ping’an , ZHANG Zhidong , YANG Peigang , LIN Yecheng , TIAN Yuan , XU Xiaosheng , WU Juan , LIU Ying , GUO Honghai , LIU Yang , WANG Dong , TAN Bibo , LI Yong , ZHAO Qun . Clinicopathological characteristics and prognostic analysis of leptomeningeal metastasis from gastric cancer [J]. China Oncology, 2021, 31(2): 126-135. |
[15] | HE Guoyang , , CHEN Qingqing , DENG Meijing , WANG Gaoxiang , WANG Beixi , WANG Yongxia , , LI Wei , QIAN Xinlai , , ZHU Huifang , . Effect of DIAPH3 on proliferation, migration and invasion of gastric cancer cells and its molecular mechanism [J]. China Oncology, 2021, 31(12): 1174-1184. |
Viewed | ||||||
Full text |
|
|||||
Abstract |
|
|||||
沪ICP备12009617
Powered by Beijing Magtech Co. Ltd