Abstract: Tumor microenvironment is composed of immune cells, fibroblasts and endothelial cells, and proliferation, invasion and metastasis of tumor cells are regulated by tumor microenvironment. Therefore, targeting both tumor cells and the surrounding microenvironment should be included in the comprehensive treatment of breast cancer. In this review, we summarized the prognostic value of the tumor microenvironment in breast cancer and how to increase the therapeutic effect of anti-cancer therapy through addition of anti-microenvironment therapy.

Key words: Breast cancer, Tumor microenvironment, Immunotherapy