China Oncology ›› 2022, Vol. 32 ›› Issue (9): 818-826.doi: 10.19401/j.cnki.1007-3639.2022.09.009
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ZHANG Jingchen(), LI Xin, LI Jiangtao, LI Haiping, CHEN Yanli, NIU Bing, QI Chuanchuan, YE Beibei
Received:
2022-01-06
Revised:
2022-03-25
Online:
2022-09-30
Published:
2022-10-24
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ZHANG Jingchen
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ZHANG Jingchen, LI Xin, LI Jiangtao, LI Haiping, CHEN Yanli, NIU Bing, QI Chuanchuan, YE Beibei. LINC02163 targeting miR-338-3p affects proliferation, invasion and migration of breast cancer cells[J]. China Oncology, 2022, 32(9): 818-826.
Tab. 2
Compare of c-Myc, MMP2, MMP9, E-cadherin, and N-cadherin protein expression in each group of MDA-MB-231 cells"
Group | MMP9/β-actin | MMP2/β-actin | c-Myc/β-actinc | N-cadherin/β-actin | E-cadherin/β-actin |
---|---|---|---|---|---|
Control | 1.62±0.22 | 1.23±0.17 | 1.50±0.25 | 1.04±0.10 | 0.43±0.06 |
sh-NC | 1.61±0.25 | 1.22±0.18 | 1.49±0.23 | 1.03±0.09 | 0.42±0.08 |
sh-LINC02163 | 0.68±0.03* | 0.33±0.06* | 0.52±0.08* | 0.21±0.05* | 1.40±0.21* |
sh-LINC02163+inhibitor-NC | 0.67±0.05 | 0.34±0.05 | 0.53±0.07 | 0.20±0.03 | 1.41±0.25 |
sh-LINC02163+miR-338-3p inhibitor | 1.28±0.12# | 1.15±0.10# | 1.40±0.22# | 0.89±0.08# | 0.70±0.11# |
Fig. 8
Comparison of tumor-forming ability and Ki-67 proliferation index of MDA-MB-231 cells in each group A: Nude mouse tumor pictures; B: tumor volume; C: Tumor weight; D: Ki-67 proliferation index (×200). *: P<0.05, compared with control group; #: P<0.05, compared with sh-LINC02163 group."
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