China Oncology ›› 2017, Vol. 27 ›› Issue (3): 237-240.doi: 10.19401/j.cnki.1007-3639.2017.03.013

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Current progress on the relationship between inflammation and postoperative cognitive dysfunction

LU Yan, CHEN Jiawei, MIAO Changhong   

  1. Department of Anesthesiology, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China
  • Online:2017-03-30 Published:2017-04-12
  • Contact: MIAO Changhong E-mail: anesthesiology@hotmail.com

Abstract: Postoperative cognitive dysfunction (POCD) is a serious central nervous system complication after general anesthesia and surgery. Its risk factors are very complex, and the mechanisms of POCD are still unclear. Recently, the role of inflammation, especially cancer related inflammation, in the development of POCD is of great interest. In this review, we focus on inflammation, and try to clarify the effect of anesthetics and anesthesia on inflammation and POCD. This review aimed to provide a theoretical basis of choosing appropriate anesthetics and anesthesia for these patients, especially the cancer patients, who are vulnerable to inflammation and POCD.

Key words: Inflammation, Postoperative cognitive dysfunction, Tumor, Anesthesia